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8 INFLUEIS^CE OF TEMPERATURE ON blood with which the organ is supplied, bnt is a normal in- gredient of the hepatic tissue. These results must, bejond all doubt, be taken as repre- senting the nearest approximation to the truth yet reached, and as constituting an exceedingly important modification of Bernard's early statements relative to the quantity of sugar normally present in the liver. The incidents of the discovery and isolation of the glycogenic matter, whose existence had been for several years suspected by its discoverer, and the repeated and prolonged discussions of the subject before the Parisian Academy, are well known- ^N^otwithstanding much ill-conceived and some unfair criti- cism, Bernard's fundamental views respecting the nature and proximate destination of glycogen have survived, and may now be said to be universally accepted. In his original paper of March 23, 185Y, Buy Tylenol 4 With Codeine Online Bernard speaks of the method of isolating the glycogenic matter. The next year Kekule confirmed the statements of Bernard, Hensen, and Pelouze with regard to its chemical status and pix)perties. It is an amorphous white substance, giving, with iodine, a violet or reddish-brown color. Its aqueous solution is opalescent, but becomes clear on boiling with dilute sulphuric acid, or when a little saliva is added, with maintenance of a proper temperature. Prolonged ebullition with acids is requisite for its complete conversion into glucose. Kekule's formula for it was-GgHjjO-s. The liver of dogs contains as much on an average -as two per cent, of glycogen. Our knowledge of the glycogenic function of the liver may be Tylenol Cold And Sinus Coupons fairly Tylenol Precise Pain Relieving Cream summed up, Can You Buy Tylenol 3 In Canada in brief, as follows : 1. The induction of dextrinoid and amylaceous matter, and of sugar, from the digestive tract effects a prompt increase of glycogen in the liver-cells. Under these circumstances a freshly -made decoction of the liver is opalescent. Even in fast- ing camivora glycogen is found in the healthy liver, and must therefore be formed from the elements of the blood. It is highly probable that glycogen originates in a decomposition of fibrinous or other proteinoid matter, principally brought to the liver by the vena portse, but in part, perhaps, also by the hepatic artery. TKANSFOEMATIONS OF GLYCOGEN, ETC. 9 2. Gljco<^en is more nearly Tylenol Arthritis Gel Caps allied to Where Can I Buy Tylenol In The Uk dextrine than to starch, and is converted into hepatic sugar by all agencies capable of converting dextrine into glucose, with a facility far greater than is observable for dextrine of vegetable origin. In this facile (convertibility glycogen is like hepatic sugar itself. 3. A certain zymogenous agency resident in the liver or hepatic blood must be invoked as the cause of this change of glycogen into hepatic sugar — a transformation which takes place with great ease at the temperature normal to the liver, but with far less readiness at lower temperatures. This con- Tylenol 3 Over The Counter In Canada version is normally in constant progress, so that the blood escaping by the hepatic veins always contains glucose in small but very constant quantity. It is probable that the sacchari- fication of glycogen does not occur in the cells of the liver, but only begins either in the cellular interspaces or in the radicles of the hepatic veins. Even systemic blood is able to saccharify glj'cogen at the temperature of the body. 4. The glucose thus constantly formed is rapidly borne away by the blood toward Tylenol Precise Coupons the lungs. If the animal be in digestion its quantity is considerably greater than usual, and much of it escapes through the left side of the heart into the Order Tylenol 3 Online general circulation. This seems to be the case habitually with herbivorous animals, which are more or less Tylenol 3 Canada Over The Counter in digestion at all times ; but in fasting carnivora, most of the sugar is destroyed in the lungs, though a certain very small portion may be regarded as normally present in the systemic Buy Tylenol 3 Online Canada blood, having escaped the peculiar decompositive influences of the pneumo-cardiac circulation. It is here that glucose is chiefly destroyed, though it finally disappears in the blood-mass, per- haps in consequence of repeated transits through the lungs ; at least it never appears normally in any of the secretions, I have thus briefly sketched the status of glycogenetic theory, as preliminary to a detail of experiments bearing upon the disappearance of sugar in the blood — a subject, as I have remarked, hitherto but little studied. This omission seems to be greatly due to the influence of Bernard's hypothetical views concerning the signification and uses of sugar in the economy. Buying Tylenol 3 In Canada His hypothesis of " animal germination " led him 10 INFLUENCE OF TEMPERATURE ON to attach Where To Buy Tylenol 3 far greater importance to the origin of sugar than to its disappearance, which he appears to have regarded as not dilFering essentially in physiological import from the ex- cretion of any of the admittedly effete crystalloidal products of nutrition, such Buy Tylenol 4 Online as uric acid, urea, Can I Buy Tylenol 3 Over The Counter and saline bodies. I have never Tylenol Sinus Coupon been able to look upon the disappearance of sugar in this light, for we cannot surely regard as an effete substance one which results from such elaborate processes, and which is undoubtedly subjected to a decomposition within the body, attended by the evolution of a very considerable share of heat, heat being largely developed also by the direct oxidation of the jproducts of this decomposition. It is not philosophical to re- gard the origin or the disappearance of sugar as more import- ant the one than the other, nor to entertain teleological views with respect to the uses of a substance plainly transitory. Bernard comj^ared the presence of sugar in the liver to its formation in the germinating seed, assuming that saccharine matter was in some way indispensable or favorable to cell- proliferation. He does not appear to have appreciated the general significance of the series of chemical changes amid which sugar presents itself, Fda Recalls Tylenol nor to have seen that what is here observed is the analogue of similar processes continually ad- vancing everywhere in the system, viz., the various processes of decompositive metamorphosis. Indeed, Bernard adopted bis peculiar views, although he was quite aware that those above expressed were entertained as long ago as 1852, and set forth in an important though short memoir, communi- cated by Bernard Tylenol Gel Caps Recall himself to the Academy on the part of its author, Moleschott, Professor of Physiology in Heidelberg. "VYe must legitimately designate the sugar formed in ger- minating seeds, or in the process of malting grain, and in the buds and succulent parts of vegetables, as a product of retro- gressive decomposition, quite as much so as in ripening fruits or stalks. In the animal economy sugar must be likewise regarded as Tylenol Extra Strength Gel Caps one of the resultants of the nutritive activity by which new compounds are incessantly built up and decom-

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